The positive expression rates of SATB2 in POMCs and MGMCs derived from upper gastrointestinal tract primary tumours were only 3.1% (1/32) and 4.3% (1/23), respectively, and the positive expression rate was up to 90.5% (19/21) in MGMCs from lower gastrointestinal tract tumours (P < 0.001). Here, SATB2 is linked to neoplasm.