In physically active individuals and patients with peripheral arterial disease, exercise training enhances endogenous fibrinolytic activity, manifested as a decrease in plasminogen activator inhibitor and an increase in tissue-type (tPA) and urokinase-type plasminogen activator (uPA) activity; these results suggest that regular exercise improves fibrinolytic activity [67–69]. The gene discussed is PLAU; the disease is peripheral arterial disease.