Only weak or negative staining of TEM1 (9 positive, 45%), MMP-2 (3 positive, 15%) and MMP-9 (2 positive, 10%) were detected in normal uterine myometrium. This suggested that MMP-9 might not play an important role in tumorigenesis of uterine leiomyosarcoma (Table 1). This evidence concerns the gene MMP2 and leiomyosarcoma.