Moreover, the correlation curve in Fig. 1C revealed a significantly positive correlation between TEM1 and MMP-2 expression (r squared = 0.6487, Pearson r = 0.8054, P < 0.0001), suggesting a functional association between TEM1 and MMP-2 in promoting tumor progression of uterine leiomyosarcomas. This evidence concerns the gene MMP2 and leiomyosarcoma.