Indeed, more than 33% (247/699) of the down-regulated genes in tumors were also down-regulated in the non-tumoral mucosa upon Taf4 inactivation (compare Supplementary Tables 2 and 11), and these 247 genes were associated with KEGG pathways designating hematopoietic cell lineages, Th1 and Th2 cell differentiation, antigen processing, graft-versus-host disease, and allograft rejection (Fig. 8H). This evidence concerns the gene TAF4 and graft versus host disease.