Some studies performed in various cell lines, but also in a xenograft model of human non-small cell lung cancer, highlighted no or decreased stabilisation of HIF-1α levels after C-ions with decreased invasion/migration, whereas increased levels of HIF-1α were correlated with increased migration in response to photons [3, 4, 49, 72]. The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.