The upregulation of CCR7 on “helped” cDC1 is intriguing, since cDC1 depend on CCR7 to migrate from the TME into draining lymph nodes for tumor-specific T-cell priming in mouse models48 and the tumor-infiltrating DC317 and DC_S318 that are found in the TME of diverse cancers express CCR7. The gene discussed is MPPE1; the disease is cancer.