CD4 and neoplasm: In vitro generated moDC (Supplementary Fig. 10a, b) essentially behaved like our ex vivo isolated moDC in that they did not specifically respond to activated CD4+ T-cells as compared to naïve CD4+ T-cells (Supplementary Fig. 10c) and did not relay help for tumor-cell associated antigen cross-priming as compared to the helped cDC1 (Supplementary Fig. 10d, e).