All above-mentioned DC signatures significantly associated with longer OS in the TCGA melanoma cohort (Fig. 5f), with the lowest significance in case of the tumor-infiltrating DC3 signature (HR = 0.63; p = 6.1 × 10−5) and the highest significance in the shared signature between “helped” cDC1 and DC_S3 (HR = 0.5; p = 5.2 × 10−7) (Fig. 5f). This evidence concerns the gene MPPE1 and melanoma.