To examine whether the senescence induction is a common role of RBM4, we stably knocked down RBM4 in a panel of human cancer cells, including HeyA8 (ovarian cancer), HCT116 (colon cancer), HeLa (cervical cancer), and 786 O (renal cancer) (Fig. S2B). The gene discussed is RBM4; the disease is ovarian carcinoma.