Findings of an inverse correlation between EZH2 and RORα protein levels in breast cancers, where protein levels of EZH2 are increased and RORα reduced30, suggest that part of the oncogenic role of EZH2 could also be through facilitation of the degradation of RORα described above since RORα is a known tumor suppressor in breast cancer. This evidence concerns the gene EZH2 and breast carcinoma.