ELP1 and Fabry disease: To more directly address the impact of Elp1-driven neurodegeneration on the gut-metabolism axis, we leveraged a previously described murine model of FD where Elp1 is specifically ablated in approximately half of peripheral neurons (including enteric neurons) and in the vast majority of neurons of the central nervous system (Tuba1a-cre+; Elp1loxp/loxp hereafter referred to as FD mice34,35).