In this study, we performed untargeted and targeted lipidomic analyses to determine the global lipid profiling in a progressive AD-like dermatitis of Spade mice that can spontaneously develop pruritic dermatitis by the mutation of the gene encoding Janus kinase 1 (Jak1), causing constitutive activation of Jak1 signaling (33). Here, JAK1 is linked to Alzheimer disease.