After co-culture with CHLA-20 tumor cells, more M1-related pathways were enriched in CAR-Ms, namely response to type I IFN, inflammatory response, response to IFNγ, cellular response to reactive oxygen species, leukocyte migration involved in inflammatory response, and leukocyte chemotaxis involved in inflammatory response (Figure 3L). The gene discussed is IFNG; the disease is neoplasm.