CD47 and neoplasm: However, the neuroblastoma tumor microenvironment is enriched with macrophages (Frosch et al., 2021), and recent data indicate that macrophages could be important mediators of antitumor responses against neuroblastoma in the context of anti-GD2 (redirecting against the tumor) and anti-CD47 (blocking phagocytosis inhibitory pathway) dual-antibody therapy (Theruvath et al., 2022).