ACD and AD are mainly T cell‐mediated skin disorders,[8, 9] and interferon gamma (IFN‐γ) and IL‐4 secreted from effector T cells are the primary cytokines that invoke the inflammatory reaction in ACD and AD.[10, 11] Inhibiting the proliferation and activation of effector T cells is becoming an effective and promising strategy for treating ACD and AD. This evidence concerns the gene IL4 and Alzheimer disease.