IGHE and allergic disease: In addition, IgE Abs secreted by B cells is the most important immunoglobulin triggering allergic reaction,[43] in which allergen‐specific IgE Abs bind to surface receptors on mast cells and eosinophils and cross‐links with antigen, causing the secretion of inflammatory mediators.[44] More and more research reveals that Th2‐released IL‐4 is critical for the induction of IgE+ B cells in the spleen.[45] Our data in Figure 5E; and Figure S15 (Supporting Information) show that α‐melittin‐NP treatment efficiently controlled the serum IgE level and IgE expression in spleen.