Soluble antigens, pro‐inflammatory cytokines, such as TSLP, and antigen‐loaded DCs quickly infiltrate LNs, inducing the activation and proliferation of antigen‐specific effector and memory T cells in LNs and resulting in aggravated disease during the pathogenesis of ACD and AD. The gene discussed is TSLP; the disease is granular corneal dystrophy type II.