P27 is critical for the establishment of the G1/S checkpoint in response to DNA damage in p53‐defective cells.[11] whereas our data now establish that LIMp27 plays an important role in p27 regulation (Figure 3a).[11] Based on these results, we tested whether LIMp27 was involved in regulating cell responses to DNA‐damaging therapeutics in the context of COAD. This evidence concerns the gene CDKN1B and colon adenocarcinoma.