P27 is critical for the establishment of the G1/S checkpoint in response to DNA damage in p53‐defective cells.[11] whereas our data now establish that LIMp27 plays an important role in p27 regulation (Figure 3a).[11] Based on these results, we tested whether LIMp27 was involved in regulating cell responses to DNA‐damaging therapeutics in the context of COAD. Here, TP53 is linked to colon adenocarcinoma.