Several studies [25, 34–36] have reported hypertension as the most common comorbidity among COVID-19 patients and as a lead risk factor for developing severe COVID-19 [37], which has been suggested to be associated with upregulation of ACE2 gene expression, encoding for the receptor used by SARS-CoV-2 [38, 39]. The gene discussed is ACE2; the disease is Hypertension.