The selective effects on palmar fibroblasts fromDupuytren’s patients is an important observation as the disease predominantlyaffects the palm of genetically susceptible individuals and we subsequently showedthe importance of epigenetic signalling in Dupuytren’s disease (Williams et al., 2020).Unlike TNF, other proinflammatory cytokines IL-6 and IL-1β had no effect on thecontractility of any of the cells. This evidence concerns the gene TNF and Dupuytren Contracture.