Consequently, the unique upregulation of TGF‐beta family genes TGFB1, TGFBR2, TGFBI, TGFB1I1, and TGFB3 in S‐ECM could be due to increased production of TGF‐beta by CAFs in the tumor microenvironment [33]. This evidence concerns the gene TGFB3 and neoplasm.