Numerous studies have shown that the interaction between tumor cells and immune cells is essential for cancer development; tumor-infiltrating immune cells affect patient prognosis and antitumor efficacy.[29] This study showed that MAD2L1 is significantly positively correlated with various immune cells, including B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells, in HCC. This evidence concerns the gene CD4 and hepatocellular carcinoma.