It has been demonstrated that MAD2L1 is associated with deoxyribonucleic acid repair, G2M checkpoint, p53 signaling pathway, PI3K/AKT/mTOR signaling pathway, and Wnt/β-linked protein signaling pathway in HCC.[11] Based on the results of this study, we suggest that MAD2L1 could be used as a potential marker for predicting HCC prognosis. The gene discussed is MTOR; the disease is hepatocellular carcinoma.