HCP5 is significantly and highly expressed in HCC tissues compared with normal tissues.[27] rs2244546 in HCP5 is a novel susceptibility locus for HCV-associated HCC development.[28] The HCP5/miR-139-5p/MAD2L1 axis has been identified as a potential regulatory pathway in HCC. The gene discussed is HCP5; the disease is hepatocellular carcinoma.