SCD and major depressive disorder: Moreover, amyloid-positive and amyloid-negative SCD+ showed similar prevalence of at least mild (ie, HADS score at least 8) anxiety (30% [8 of 27] vs 13% [10 of 78]; χ2 = 2.9; P = .09) or depression (11% [3 of 27] vs 4% [3 of 78]; χ2 = 0.8; P = .36) symptoms at follow-up (Figure 2).