This represents another important point in our study as it identifies these three features as highly useful in differentiating tumours with a high risk of metastasis and high Ki-67 values: these tumours are therefore more inhomogeneous due to the presence of necrosis or colliquation from those with a low tendency to metastasise and with low grading, thus allowing the early identification of those tumours at high risk [35]. This evidence concerns the gene MKI67 and neoplasm.