CACNA1C and bipolar disorder: Large-scale genome-wide association studies (GWAS) have consistently identified several risk-conferring genetic variants for adult BD, including the single nucleotide polymorphism (SNP) rs1006737 at the calcium channel, voltage-dependent, L-type, alpha-1C subunit (CACNA1C) gene locus (Ferreira et al. 2008; Psychiatric GWAS Consortium Bipolar Disorder Working Group 2011).