IL6 and atrial fibrillation: One potential cause of POAF is post-surgical inflammation, indicated by increased levels of inflammatory biomarkers such as CRP and Il-6.25 Although still a matter of debate, the role of these inflammatory biomarkers in the pathogenesis of POAF remains a subject of intense research.23 Anti-inflammatory agents used after CABG and/or valve surgery are an indication that inflammation plays a contributing role to POAF and reduce the incidence of AF.21