The TCGA and GSE16011 cohorts with the largest size of LGG and GBM were combined and used as the training set, which consists of 736 patients with clinical information, including IDH mutant (IDH-mt, n = 442) and IDH-wt (n = 215) as well as 1p/19q-cd (n = 409) and non-co-deletion (1p/19q-ncd, n = 191). Here, IDH2 is linked to glioblastoma.