TP53 and cancer: The KEGG enrichment analysis revealed that p53 signaling pathways, viral carcinogenesis, proteoglycans in cancer, and the PI3K-AKT signaling pathway were positively associated with up-regulated differentially expressed genes, while tyrosine metabolism, tight junction, retinol metabolism, the PPAR signaling pathway, and drug metabolism were highly correlated with down-regulated differentially expressed genes.