A report on TBI-induced coagulopathy indicated that fibrinolytic D-dimer and FDPs are first detected within minutes after injury, and that prolonged prothrombin and partial thromboplastin times peak at ∼3–6 h after TBI.31 Moreover, D-dimer, which is a fibrinolytic factor, is increased in patients with TBI, with increased fibrinogen consumption during the acute phase of TBI.32 Our results are consistent with previous literature, and suggest that the patients with contrast extravasation may have had more severe TBI-induced coagulopathy. The gene discussed is F2; the disease is blood coagulation disease.