TOP2A and nonpapillary renal cell carcinoma: By correlation analysis, we obtained the top 300 genes most associated with CENPM, and the top 20 molecules were shown by heat map in Fig. 5A. 109 of the 300 genes were differentially expressed in ccRCC (Fig. 5B), and the PPI network of these genes is shown in Fig. 5C. Based on the centrality of the nodes, we found that CCNA2, CDC20, AURKB, ASPM, BUB1, TOP2A, and CCNB2 are perhaps the most critical molecules associated with CENPM in ccRCC.