CTPS2 and B-cell chronic lymphocytic leukemia: In addition, it was validated that the CLL patients with CTPS2 overexpression had a significant decrease in overall survival both in GSE22762 (HR = 4.488, p = 0.001, Fig. 2C) and ICGC database (HR = 1.614, p = 0.049, Fig. 2D).