Deletion of either Eed or Ezh2 disrupted PRC2 function, as both M-Smo/EedcKO and M-Smo/Ezh2cKO showed minimal H3K27me3 in tumor cells, with residual H3K27me3 in interspersed stromal cells demonstrating the effectiveness of the staining technique (Fig. 5B). Here, SMO is linked to neoplasm.