Further, the most commonly adopted biodegradable synthetic and natural polymers to develop this kind of NPs are poly(lactide-co-glycolide) (PLGA) [270], polylactide (PLA) [271], polycaprolactone (PCL) [272], PLGA-polyethylene glycol (PEG) [273], alginate [274], gelatin [275], albumin [276], etc. Recently, an investigation by Wang and colleagues developed DOX-loaded cRGD-attached reduction-responsive crosslinked nanotherapeutics based on star PLGA-lipoic acid conjugate (cRGD-sPLGA XNPs) to achieve targeted delivery to melanoma (Fig. 8) [277]. The gene discussed is ALB; the disease is melanoma.