Some of the recent MNs-based approaches that demonstrated efficient skin cancer therapy include 5-fluorouracil, indocyanine green/ PCL NPs/ HA MNs/ epidermoid carcinoma, melanoma [280], Cu-doped polydopamine NPs (PDT)/ PVP-PVA MNs/ melanoma [380], STAT3 siRNA/ dextran-PVP-HA MNs/ melanoma [381], curcumin, indocyanine green/ HA-alginate-gelatin MNs/ melanoma [382], doxorubicin, trametinib/ dextran methacrylate hydrogel MNs/ melanoma [383]. The gene discussed is STAT3; the disease is melanoma.