In addition, the mice group treated with free CP lost their body weight significantly (10–15%) and indicated several side effects such as heavy breathing, aggravated moving, vocalizations, etc. However, no side effects were observed in the mice group treated with CP@MSNs apart from mild to negligible nephro- and hepatotoxicity, which did not affect the mice to a greater extent, ensuring MSNs are the prominent candidates in effective melanoma treatment without involving severe side effects. This evidence concerns the gene CP and melanoma.