APOE and Hypertension: Multivariable analyses including significant predictors from univariate analyses showed that only the presence of cSS (HR, 7.38; CI 1.42–38.44) and previous lobar ICH (HR, 5.07; CI 1.23–20.87) were associated with ICH development but not hypertension, smoking, and APOE genotypes (Table 2).