In univariate analyses, hypertension (hazard ratio (HR), 0.24; confidence interval (CI), 0.05, 1.16), anticoagulant use (HR, 7.89; CI 0.75–83.5), presence of cSS (HR, 1.02; CI 0.93–1.12), APOE2 (HR, 5.33; CI 1.4–20.25), APOE4 (HR, 0.14; CI 0.02–1.0), and previous lobar ICH (HR, 9.3; CI 2.48– 34.9) were associated with ICH development. The gene discussed is APOE; the disease is Hypertension.