As shown in Fig. 6 and Additional file 1: Table S13, the RSS-high group was significantly enriched with cell-cycle related pathways such as mitotic spindle, E2F targets, G2M checkpoint, MYC targets, DNA replication, and DNA repair-related pathways such as base excision repair, nucleotide excision repair, mismatch repair, and several cancer-related pathways such as WNT/beta-catenin signaling, Notch signaling, and angiogenesis (all P < 0.05). This evidence concerns the gene CTNNB1 and cancer.