ATP2A2 and cardiac arrhythmia: Oakley analyzed the signal pathways related to dysregulated genes, and the results showed that the mechanism of glucocorticoids on POAF might be as follows: improving the expression of voltage-gated L-type calcium channel (LTCC), sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase 2 (SERCA2), sodium/calcium exchanger 1 (NCX1) and RyR2 genes, this result has important reference value for the pathological study of POAF [60, 61]; this abnormal expression may contribute to the development of arrhythmias.