Although the frequency of CD4+CXCR5−FOXP3+ T cells in the HBV-infected patients was comparable with HC subjects (Fig. 2A), eAg−CHep patients showed notable reduced CD4+CXCR5−FOXP3+ T cell frequency in comparison to eAg+CInf, eAg−CInf, and hepatic failure patients. The gene discussed is KCNH1; the disease is Hepatic failure.