Although no PTBP1 inhibitors suitable for gastric cancer treatment were identified, our findings demonstrate that PTBP1 exerts antitumor effects can be mediated through downstream c-Myc, which is one of the key targets for gastric cancer treatment, not only promoting gastric cancer progression and lung metastasis [53], but also involved in the induction of PD-L1 expression [54]. This evidence concerns the gene MYC and gastric cancer.