The present study is designed for efficient delivery of F. cretica L. plant extract based albumin, liposomes and silver nanoparticles for in vitro anticancer potential against MCF-7, Hep-2 and HUH-7 cancer cell lines along with the plant nanoparticles based treatment dependent transcriptional level expression modulation of apoptotic pathway associated genes TRAIL, DR4, DR5, FADD and TP53 as natural cell death mechanism induction therapeutic option for cancer. This evidence concerns the gene TP53 and cancer.