NK cell engager molecules targeting CD123 on AML cells and engaging NKp46 (NKp46-Fc null-CD123), or coengaging NKp46 and CD16a (NKp46-Fc-CD123: CD123-NKCE) on NK cells (Fig. 2a and Supplementary Figs. 1 and 2) were generated. This evidence concerns the gene IL3RA and acute myeloid leukemia.