NK cell engager molecules targeting CD123 on AML cells and engaging NKp46 (NKp46-Fc null-CD123), or coengaging NKp46 and CD16a (NKp46-Fc-CD123: CD123-NKCE) on NK cells (Fig. 2a and Supplementary Figs. 1 and 2) were generated. The gene discussed is IL3RA; the disease is acute myeloid leukemia.