This dataset, comprised of ER-positive, PR-positive, HER2-positive and TNBC, showed a distinct clustering (Fig. 4M–O), with multiple EPCAM+ and Keratin-8+ (KRT8) clusters corresponding to the heterogeneous tumor cell populations in each of the breast cancer subtypes (Supplementary Fig. 8I). This evidence concerns the gene KRT8 and neoplasm.