Isolation and culture of EpCAM-positive tumor cells, EpCAM-negative tumor cells and tdTomato-positive CAFs derived from the same WB1P-Myc tumors showed that both EpCAM-positive and EpCAM-negative tumor cells lacked the ability to remodel collagen and gave rise to mammary tumors upon orthotopic re-transplantation. This evidence concerns the gene EPCAM and breast cancer.