Owing to the small size of tumor tissue in the sh-circMBOAT2 group, we took material from the other 3 groups and performed IHC staining, which revealed an increased proportion of proliferating cells (Ki67+ and PCNA+) in the upregulated expression of circMBOAT2 group compared with the control group (Fig. 2H, J). The gene discussed is PCNA; the disease is neoplasm.