IFNG and lung cancer: In vitro analysis of differentiation and activation of macrophages obtained from human peripheral blood mononuclear cells showed that the level of HS2/HS3 transcripts were declined by day 8 of differentiation from monocytes to macrophages (Fig. S6B) and also in response to conditioned media (CM) from human lung cancer cells or to a combination of IFNγ and lipopolysaccharide LPS (M1-like subtype).