Remarkably, HFL1 with depleted satellite RNAs were not able to induce transcription of many inflammatory genes (e.g. IL6, IL8, IL1β, CXCL1) in coculture with lung cancer cells (Fig. 5A), whereas expression of myCAF genes (COL1A1, COL4A1, αSMA, HAS2, FN1, COL11A1) did not differ much between control HFL1 and si-HS2/HS3 transfected. The gene discussed is IL6; the disease is lung cancer.