Adding a further level of complexity, YAP-activating mechanisms involved in GC also include upregulation of Methyltransferase3 (METTL3) [104], AMOTL1 [105], Fibroblast growth factor receptor type 2 (FGFR2) [106], Nucleolar and spindle associated protein 1 (NUSAP1) [107], Microtubule-associated monooxygenase, calponin and LIM domain containing 2 (MICAL2) [108], and Interferon regulatory factor 3 (IRF3) [109], as well as loss of PTEN [110] and MST4 kinase [111]. The gene discussed is YAP1; the disease is gastric cancer.