Despite lower NE and MHPG levels in the lesioned mice, we detected elevated MHPG:NE ratio in the LC and terminal regions, which has been previously reported in DSP-4-treated rodents (Hallman and Jonsson, 1984) and consistent with human AD CSF data (Francis et al., 1985; Hoogendijk et al., 1999; Raskind et al., 1999; Jacobs et al., 2021b). This evidence concerns the gene DUSP26 and Alzheimer disease.