In our study, TTN DCM type 1G, KCNQ1 LQTS type 1, MYBPC3 HCM type 4, and TMEM43 arrhythmogenic right ventricular dysplasia type 5 were the most frequent CVD, and MSH6 Lynch syndrome and PALB2 HBC were the most frequent CPC among ACMG SFs (Fig 1). Here, PALB2 is linked to arrhythmogenic right ventricular dysplasia 5.