In our study, TTN DCM type 1G, KCNQ1 LQTS type 1, MYBPC3 HCM type 4, and TMEM43 arrhythmogenic right ventricular dysplasia type 5 were the most frequent CVD, and MSH6 Lynch syndrome and PALB2 HBC were the most frequent CPC among ACMG SFs (Fig 1). The gene discussed is MSH6; the disease is Lynch syndrome.