18/24 (75.0%) ACMG SFs were related to cardiovascular diseases (CVD), among them: TTN dilated cardiomyopathy (DCM)—4; ACTC1 DCM (1); MYBPC3 hypertrophic cardiomyopathy (HCM)—2, TNNT2 DCM/HCM—1; KCNQ1 long QT syndrome (LQTS)—3; LDLR familial hypercholesterolemia (FH)—2; PCSK9 FH—1; APOB FH—1; TMEM43 arrhythmogenic right ventricular dysplasia—2; FBN1 Marfan syndrome (MS)—1. The gene discussed is ACTC1; the disease is cardiovascular disorder.