ITGB2 and cancer: Multiple long non-coding RNA (lncRNA) had been verified to be involved in the process and prognosis of various cancer types such as breast cancer, colorectal cancer, and KIRC.4-6 As a newly identified lncRNA, ITGB2-AS1 had been discovered to be abnormally expressed in breast cancer and osteosarcoma, and it could regulate the proliferation, migration and invasion of various cancer cells.7,8 However, there are few studies on the expression significance and biological functions of ITGB2-AS1 in KIRC.