TNF and Hepatic fibrosis: For example, miR-20a-5p was downregulated during liver fibrosis and transfection of miR-20a-5p reduced the production of the proinflammatory cytokines IL-6, TNF-α, IL-18, and IFN-γ in a murine hepatoma cell line by targeting transforming growth factor beta 2 (TGFB2) [27].