RARS1 and central nervous system disorder: In addition, the arginyl-TRNA synthetase 1 (RARS1) gene has been shown to be associated with various diseases of the central nervous system [50], slit guidance ligand 3 (SLIT3) located near ALGA0090878 on SSC16 is associated with the bone loss [51], and the receptor activator of NF-Kb 3 (RANK3) gene is associated with alcoholic femoral head necrosis [52].