CML originates in a single HSC with a chromosomal translocation t(9;22) that gives rise to the Philadelphia chromosome and the BCR-ABL tyrosine kinase.28, 29, 30 In addition, there is a rare blood cancer called myeloid proliferative neoplasms (MPNs) that is driven by the acquisition of mutation to a tyrosine kinase (JAK2-V617F) in an HSC.31 This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.