The relatively mild West African G6PD A− variant (10% to 60% G6PD activity), found in 39.3% of the G6PD-deficient Amazonians [56], is associated with a significant reduction in the risk of severe falciparum malaria in both male hemizygotes and heterozygous females in Africa. This evidence concerns the gene G6PD and Plasmodium falciparum malaria.