The expression of proinflammatory innate cytokines, including Th1 polarizing cytokines Il12b and Tnf; Th17/Th22 polarizing cytokines Il1b, Il23a, and Il6; and Il10 were significantly induced as compared with controls showing a similar expression profile as in rosacea (Figure 4A). The gene discussed is TNF; the disease is rosacea.