They include functional connectivity with blood glucose in diabetes: TXNIP (58–61), TTC7B (62), ANKS3 (63), chromatin determinants ARID5B and CUX1 (48), islet autoantigen PTPRN2 (64), and metabolic regulators HK1 (65), PFKFB3 (66), and NCOR2 (67). The gene discussed is TXNIP; the disease is diabetes mellitus.