IRS2 and Hyperglycemia: Taken together, these findings in tissue-specific cells show that hyperglycemia converges on major insulin, lipid, and fibrosis pathways by DNA methylation to regulate the expression of core genes that consist of but are unlikely to be limited to MTOR, RPTOR, IRS2, TXNRD1, LCAT, SMPD3, and COL1A2.