TARDBP and amyotrophic lateral sclerosis: Whilethe responsible protein is specific to each disease, such as the Amyloidβ and Tau proteins for Alzheimer’s disease,6,8−10 the α-synuclein protein for Parkinson’sdisease11 and the SOD1 and TDP-43 proteinsin the case of amyloid lateral sclerosis (ALS),12 the process leading to the formation of fibrils seems tofollow three phases in each case: a lag, an intermediary, and a saturationphase.5,13,14 A fundamentalinterest has been focused on the study of those amyloid structures,but the understanding of the intermediate structures present remainselusive.