Based on the analytical and clinical properties of biochemical markers, the group agreed on four mandatory biochemical markers evaluating musculoskeletal status that should be assessed in any new Phase II or Phase III trial, namely, the myostatin-follistatin couple, BDNF, PIIINP and the Sarcopenia Index [using the formula (serum creatinine (mg/dL)/serum cystatin C (mg/L)) ×100]. This evidence concerns the gene CST3 and sarcopenia.